A decade of learning about the HIV reservoir: new insights into latent infection.

One longstanding question is how cells become latently infected. In 2007, Suha Saleh (Monash University, Australia) and colleagues published an article that provided one of the first pieces of the puzzle. They demonstrated that when resting CD4+ T cells are incubated with certain chemokines and then infected with HIV, many copies of the virus are able to integrate into the cells’ genomes. [1] Sharon Lewin (University of Melbourne), the senior author of the article, observes that this study “was the first to show that latency